Joining a Real-Time Simulation: Parallel Finite-State Machines and Hierarchical Action Level Methods for Mitigating Lag Time

Distributed virtual environments, which simulate an actual physical or imaginary world on a network and allow multiple participants to interact simultaneously with one another within it, are becoming increasingly important for both research and practical purposes. As the number of participants and the amount of information exchanged among participants increase, it is crucial to large-scale distributed virtual environments to overcome bandwidth limitations and resolve network latency and synchronization problems. We present a new framework, called MELD, for modeling distributed virtual environments using the pilot/drone paradigm, which allows each host to locally model remote entities in order to resolve latency problems and improve responsiveness. Our approach uses shared event queues and a cache coherence protocol to synchronize the pilot/drone. To further improve the system\u27s scalability, interest management is used to filter unneeded data before a host receives it for processing. The partition, however, introduces the problem of dynamically joining a group in a real-time simulation. We address this problem by presenting a checkpoint/restart mechanism based on an action hierarchy and a parallel finite-state machine structure. Additionally, ALOD (action level of detail) is employed to mitigate the lag between pilot and drone at any joining time

Scalable Security Mechanisms for the Internet

The design principle of restricting local autonomy only where necessary for global robustness has led to a scalable Internet. Unfortunately, this scalability and capacity for distributed control has not been achieved in the mechanisms for specifying and enforcing security policies. The STRONGMAN system described in this paper demonstrates three new approaches to providing efficient local policy enforcement complying with global security policies. First is the use of a compliance checker to provide great local autonomy within the constraints of a global security policy. Second is a mechanism to compose policy rules into a coherent enforceable set, e.g., at the boundaries of two locally autonomous application domains. Third is the lazy instantiation of policies to reduce the amount of state enforcement points need to maintain. We demonstrate the use of these approaches in the design, implementation and measurements of a distributed firewall

Flexible Network Monitoring with FLAME

Increases in scale, complexity, dependency and security for networks have motivated increased automation of activities such as network monitoring. We have employed technology derived from active networking research to develop a series of network monitoring systems, but unlike most previous work, made application needs the priority over infrastructure properties. This choice has produced the following results: (1) the techniques for general infrastructure are both applicable and portable to specific applications such as network monitoring; (2) tradeoffs can benefit our applications while preserving considerable flexibility; and (3) careful engineering allows applications with open architectures to perform competitively with custom-built static implementations. These results are demonstrated via measurements of the lightweight active measurement environment (LAME), its successor, flexible LAME (FLAME), and their application to monitoring for performance and security

Safety and Performance in an Open Packet Monitoring Architecture

Packet monitoring arguably needs the flexibility of open architectures and active networking. A significant challenge in the design of open packet monitoring systems is how to effectively strike a balance between flexibility, safety and performance. In this paper we investigate the performance of FLAME, a system that emphasizes flexibility by allowing applications to execute arbitrary code for each packet received. Our system attempts to achieve high performance without sacrificing safety by combining the use of a type-safe language, lightweight run-time checks, and fine-grained policy restrictions. Experiments with our prototype implementation demonstrate the ability of our system to support representative application workloads on Bgit/s links. Such performance indicates the overall efficiency of our approach; more narrowly targeted experiments demonstrate that the overhead required to provide safety is acceptable

Hyporheic Exchange and Water Chemistry of Two Arctic Tundra Streams of Contrasting Geomorphology

The North Slope of Alaska’s Brooks Range is underlain by continuous permafrost, but an active layer of thawed sediments develops at the tundra surface and beneath streambeds during the summer, facilitating hyporheic exchange. Our goal was to understand how active layer extent and stream geomorphology influence hyporheic exchange and nutrient chemistry. We studied two arctic tundra streams of contrasting geomorphology: a high-gradient, alluvial stream with riffle-pool sequences and a low-gradient, peat-bottomed stream with large deep pools connected by deep runs. Hyporheic exchange occurred to ~50 cm beneath the alluvial streambed and to only ~15 cm beneath the peat streambed. The thaw bulb was deeper than the hyporheic exchange zone in both stream types. The hyporheic zone was a net source of ammonium and soluble reactive phosphorus in both stream types. The hyporheic zone was a net source of nitrate in the alluvial stream, but a net nitrate sink in the peat stream. The mass flux of nutrients regenerated from the hyporheic zones in these two streams was a small portion of the surface water mass flux. Although small, hyporheic sources of regenerated nutrients help maintain the in-stream nutrient balance. If future warming in the arctic increases the depth of the thaw bulb, it may not increase the vertical extent of hyporheic exchange. The greater impacts on annual contributions of hyporheic regeneration are likely to be due to longer thawed seasons, increased sediment temperatures or changes in geomorphology

Global energy transfer during a magnetospheric field line resonance

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95367/1/grl28194.pd

Measurement of Branching Fractions of Hadronic Decays of the Ωc0\Omega_c^0 Baryon

Using a data sample of 980 ${\rm fb}^{-1}$ of $e^+e^-$ annihilation data taken with the Belle detector operating at the KEKB asymmetric-energy $e^+e^-$ collider, we report the results of a study of the decays of the $\Omega_c^0$ charmed baryon into hadronic final states. We report the most precise measurements to date of the relative branching fractions of the $\Omega_c^0$ into $\Omega^-\pi^+\pi^0$, $\Omega^-\pi^+\pi^-\pi^+$, $\Xi^-K^-\pi^+\pi^+$, and $\Xi^0K^-\pi^+$, as well as the first measurements of the branching fractions of the $\Omega_c^0$ into $\Xi^-\bar{K}^0\pi^+$, $\Xi^0\bar{K}^0$, and $\Lambda \bar{K}^0\bar{K}^0$, all with respect to the $\Omega^-\pi^+$ decay. In addition, we investigate the resonant substructure of these modes. Finally, we present a limit on the branching fraction for the decay $\Omega_c^0\to\Sigma^+K^-K^-\pi^+$

Unconsciously Triggered Conflict Adaptation

In conflict tasks such as the Stroop, the Eriksen flanker or the Simon task, it is generally observed that the detection of conflict in the current trial reduces the impact of conflicting information in the subsequent trial; a phenomenon termed conflict adaptation. This higher-order cognitive control function has been assumed to be restricted to cases where conflict is experienced consciously. In the present experiment we manipulated the awareness of conflict-inducing stimuli in a metacontrast masking paradigm to directly test this assumption. Conflicting response tendencies were elicited either consciously (through primes that were weakly masked) or unconsciously (strongly masked primes). We demonstrate trial-by-trial conflict adaptation effects after conscious as well as unconscious conflict, which could not be explained by direct stimulus/response repetitions. These findings show that unconscious information can have a longer-lasting influence on our behavior than previously thought and further stretch the functional boundaries of unconscious cognition

Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers

Irinotecan is used clinically for the treatment of colorectal cancer; however, its utility is limited by its narrow therapeutic index. We describe the use of a generation 5 l-lysine dendrimer that has been part-modified with a polyoxazoline as a drug delivery vehicle for improving the therapeutic index of SN-38, the active metabolite of irinotecan. By conjugating SN-38 to the dendrimer via different linker technologies we sought to vary the release rate of the drug to generate diverse pharmacokinetic profiles. Three conjugates with plasma release half-lives of 2.5 h, 21 h, and 72 h were tested for efficacy and toxicity using a mouse SW620 xenograft model. In this model, the linker with a plasma release half-life of 21 h achieved sustained SN-38 exposure in blood, above the target concentration. Control over the release rate of the drug from the linker, combined with prolonged circulation of the dendrimer, enabled administration of an efficacious dose of SN-38, achieving significant regression of the SW620 tumours. The conjugates with 2.5 and 72 h release half-lives did not achieve an anti-tumour effect. Intraperitoneal dosing of the clinically used prodrug irinotecan produces high initial and local concentrations of SN-38, which are associated with gastrointestinal toxicity. Administration of the 21 h release dendrimer conjugate did not produce a high initial Cmax of SN-38. Consequently, a marked reduction in gastrointestinal toxicity was observed relative to irinotecan treatment. Additional studies investigating the dose concentrations and dose scheduling showed that a weekly dosing schedule of 4 mg SN-38/kg was the most efficacious regimen. After 4 doses at weekly intervals, the survival period of the mice extended beyond 70 days following the final dose. These extensive studies have allowed us to identify a linker, dose and dosing regimen for SN-38 conjugated to polyoxazoline-modified dendrimer that maximised efficacy and minimised adverse side effects